Sunday, May 12, 2019

Pharma marketing tips




Medico marketing tips

1) selling of the pharma drugs is possible with
 

    Knowledge

2) Scientific reports

3)  It is a  job of good product manager to gather not only


   Recent information about the drug or disease but all generations of the drug
 


   4) History makes the detailing story interesting  and one way could compete the compitator.


    5)  Recent knowledge before it is circulated in the field  is always welcome



       By the doctors

6) In my personal experience  while introducing a new product doctor instructed to hospital staff although doctor was going for emergency operation  please ask me to wait

Docttor ask me  to share all information 20 valuable minutes we're spent by doctor
7) So never think doctor is not allowing time to discuss important features
8) You should read the face of doctor when he is not interested take it as order do not keep on detailing like a Pooja you may say  good  day.

9) spending time with doctor will give a better business .
 

Tuesday, May 7, 2019

Heart Disease 2

                                Heart Disease 2

Dr Roshman and Dr Friedman  in 1950 discovered Type APersonality in heart disease 

Patients with impaired coronary circulation.Researcher were
helped by a  person whose job was to repair sofas .Once the gentalman notice in above doctor's clinic that every time unlike my other customers here the sofa requires front side stiching .He reported his clever observation to these doctors.

Dr gave a thought over it and notice that his patient are impatient and anxious so that they sit much forward part and the frequent sticking required
 They called a Type A personality .

Characteristics of Type A personality

1) competitive
2) constantly watching watch

3)Impatient

4)Do not have time for family.



Heart disease 1

                                    Heart Disease 1


During first world war Europeans had to face scarcity of food.Europiens then deprived for mutton eggs milk cheese for long time even during  post war peroid .

Post war food for Europeans , potato vegetables and legumes .


Doctor's from Finland Dr Emari and Dr Kanelha observed the number of deaths due to heart diseases significantly lowered on post war perood compare to pre war peroid.

The above Finland study disproved the theory that for heart disease the sole cause is       heriditary.

      For maintaining proper metabolic  functions of the heart balanced diet

         is requried .Simlarly stress free life is essential for normal heart functions.

        Stress was common to even our ancestors living in cave.
     
          Wild animals were constant threat to humans life in cave  .


           For running away from wild animals tiger lion one must have strong leg muscles

Required for running .Heart must supply proper blood supply .
 




         Today we have different causes for stress .we should have matching dress while going to office we should try to reach on time to office mere thought that today boss will ask if we have complited the yesterday's task will trigger our stress levels.insulting of boss in front of office staff adds to stress some times our ancestors life was better than today's boss cabin as we cannot run away from boss cabin when boss is scolding.

Economical stress adds up this finally increases  stress harmones unlike in past where our ancestors used to utilised the stress hormones by running away from threat of wild animals we give stress to heart as we cannot run away from daily stresful events.This results in hypertension heart disease.




       Astronuts blood pressure before entering space is unstable but once he reaches in space his blood pressure stabilizes


    This skill of astronuts should be implemented in day to day practice to have some control on BP.
Scientist from America carry out study  on monkeyes .There we're two groups A and B group A monkeys were kept in group in single cage . Group B monkeys were kept in isolation experiment was for 21months.All monkeys food was same.
Observation group B monkeys showed blokages in blood vessels and Group A monkeys free  from blokages .conclusion isolation increases stress and blokages on blood vessels.


 





Sunday, May 5, 2019

Tumour Markers

                         Tumour Markers 


Cancer is an abnormal growth that originates within human body and  although there are

different types of cancer but  all share hallmark of characteristic that unchecked growth 

Progress to a limitless expansion.

 Cancer grows and expands and spreads by metastasis ie some cells detached from primary tumour spreads into the even at times distant organs and establishess secondaries .
Tumor Markers required to understands the growth as we use to record the fever  using thermometer , blood sugar to monitor diabetes


Ideal tumour marker :
Be specific for the tumour
Level should change in response to tumour size

An abnormal level in response to micro metastasis
 Both sensitivity and specificity required

It should help in diagnosis and prognosis



So we can say an ideal tumour marker should be specific and sensitive.

Sensitive tumour marker value should increase even if micrometastasis grows

1) CEA : tumour marker called carcino embryonic antigent

        Cancer is back ward process so cea increases in cancer

      This test is non specific and non sensitive

Abnormal readings are seen in smokers cirrhosis

Ulcerative colitis hence first diagnosis is required and then Monitoring possible   for breast cancer pulmonary cancer and  colorectal cancer

 2)      CA--125  notice in 50percent early overian patients
   
             CA-125  increases in appendicitis, pregnancy and ovarian cyst

           The CA-125  lacks sensitivity and specificity.
            This test is useful in monitoring ovarian cancer recurrence
               and treatment .




 3)
      Ca15--3 :Not specific or sensitive enough to detect early breast cancer .


         Low value of CA15 --3 did not rule a carcinoma,an elevated value ,greAter than 35
   
       Units /ml suggested malignancy .


As a rule CA-15 should be used after the diagnosis of breast cancer .

CA15-3 elevation may be due to ling ovarian liver and colorectal
Cancer.


      4) PSA (Prostate SPECIFIC  ANTIGEN :

            Elevated in high Prostate cancer ,in benign prostate ,hypertrophy and

          Prostatits
Monitor recurrence and response to treatment