Burden Of Dietary sugars On the Liver
NAFLD Non Alcoholic Fatty Liver Disease Or metabolic dysfunction associated
Steatotic liver disease ,has increased in prevalance hand in hand
with the rise in obesity and increased free sugars in the food supply .
The causes of NAFLD are genetic in origin and combined with
environmental drivers of the disease phenotype .
Dietary intake of added sugar
Has been shown to have a major role in
phenotypic onset and progression of disease .
Simple Sugars are key drivers of steatosis,
Fueling the De novo lipogenesis .
De novo lipogenesis : in which carbohydrates from. circulation are converted into
fatty acids ---------
------- Converted in to Triglycerides ---
--- Lipids molecules they are fatty compounds
The conversation of excess carbohydrates into
fatty acids triggers hyperinsulinemia another driver for NAFLD
NAFLD burden is associated with obesity Type 2 diabetes metabolic syndrome
And cardiovascular disease.
IMP Dietary Sugar in NAFLD Pathogenesis.(Disease development)
NAFLD or metabolic dysfunction is associated Steatotic liver
disease described
In early 1800
The increasing prevalance of NAFLD is linked to rise in
Sugar consumption.
Sugar Taxation:
1)Is cost effective policy option to reduce the health and economic
Burden related to the over consumption of added sugars.
2 Sugar taxation is viable strategy in many countries (eg Mexico
Denmark and South Africa )and US juridictions (eg Berkly,
California)
Sugar reduction for NAFLD is required
Life style changes is the first line therapy for NAFLD to
Prevent the development of NAFLD and it's complications.
Children's are most vulnerable so the Strategies:
Used 1Food education
2 Distribution of fruits and vegetables at school,and
Increased taxes of foods that contain any from of added sugar .
Glucose and fructose are combined in table sugar
Or called as sucrose
What is the difference between Glucose and fructose
Glucose : intake stimulates insulin secretion from
Pancreatic Beta cells
Fructose: has negligible impact on circulating
Insulin levels.
Fructose bypasses Leptin (Satiety Hormone)
And atunates secretion of Gherilin (the hunger Hormone .)
The consumption of fructose has increased by 30%
In last 40 years and 500% over the last century due to increased
Consumption of processed food and sugar Sweetened Beverage
(SSB)
.
.
NAFLD Characterized by Steatosis occuring >5% of hepatocytes(
Important cells of liver) in the absence of alcohol consumption.
NASH or metabolic dysfunction associated with Steato hepatitis
(Inflamation)
Which can progress to fibrosis and cirrhosis .Predisposing
patients to HCC (Hepatocellular Carcinoma liver cancer)
NAFLD closely associated to Type 2 diabetes , metabolic syndrome
Polycystic ovarian syndrome obesity,Dyslipedimia,and
Cardiovascular Disease (C VD)
In USA prevalance of NAFLD has risen to ≥34%in adults
Excessive dietary sugar intake has
A major role in the onset and progression of NAFLD
(Non Alcoholic Fatty Liver liver Disease
Ref Hepatology Commun 2023 Nov ,7(11)eO297
Helaina E Hunneault
Ana Ramirez Tovar
Cristian Sanchez Torres
Jean A welsh
Miriam B Vos
