B Vitamins for stroke Prevention
Ref 1Medicine (Baltimore) 2019 Mar :98(12)
e14872
Biai Pan
Xiao Jinz
Liu Jun , Shaohong Qiuping Zheng and
Ming Wo Pan
Stroke is called as Brain attack
Stroke known as an acute cerebrovascular
Event closely related to brain tissue injury,
Is one of the leading cause of death and dis
ability for adult men and women world
Wide.
According to world Health Organization
Every year approximately 15million people
have A stroke.
87% are classified as ischaemic strokes
Ischaemic means lack of blood supply
To a part of body
10% are intra cerebral (bleeding inside brain)hemorrhagic stroke
03% subarachnoid (bleeding between brain
And tissue covering brain) hemorrhagic stroke.
Ref 2 Int J Mol Sci 2020 Oct :21(20):7609
Diji Kuriakose and Zhicheng Xiao
Stroke is the second leading cause of death
A major contributor to disability world wide.
Stroke is a neurological disorder characterized
By blockage of blood vessels .
Clots from in the brain and interrupt
Blood flow ,clogging arteries leading to brain
During stroke results in sudden death of brain
Cells owning to lack of oxygen stroke can also
Lead to depression and dementia.
Ref 3 Stroke Vascular Neurology
2018 Jun :3(2):51-58
Graeme J Hankey
The homocysteine (homocysteine derived
From essential amino acid methionine).
The homocysteine hypothesis
Hypothesis that B vitamin therapy
(Folic acid ,Vit B6 and Vitamin B12)
May prevent stroke.
Emerged more than 15 years ago after
Early case and epidemiological studies
Reported an association between plasma
Concentration of homocysteine and
Incidence of cardiovascular disease,
Laboratory studies reported atherogenic(
Tending to promote the formation of
Fatty deposits in the arteries)
And thrombogenic ( coagulation
Of blood substance or condition)
properties of high
tHcy and randomised control trials
(RCTs) showed that supplementation with
B Vitamins lowers tHcy.
Supplementations with B
Vitamins B9 (Folic acid)
Vitamin B12 and B6 lowers blood
Total homocysteine tHcy concentration
By about 25% and reduces the
relative risk of stroke by about 10%
Risk Ratio (RR)0.90,95%CI 0.82to 0.99
Compare with placebo
Clinical trials indicate that countries
Which mandate folic acid fortification
Of foods folic acid supplementation has no
Significant effect on reducing stroke risk
(RR 1.05,95% CI 0.90 to 1.23)
However in countries without mandatory
Folic acid supplementation reduces the risk
Of stroke by about 15%(RR 0.85,CI 0.7 7 to
0.94)
