Gut microbiota obesity prognosis of breast cancer

 Ann Med. 2026 Jan 7;58(1):2611203. doi: 10.1080/07853890.2025.2611203

The gut microbiota-obesity axis in the pathogenesis and prognosis of breast cancer

Huiyue Zhang a,b, Yue Wang a,b, Benyi Ning a,b, Yiwen Wang a,b, Tao Sun a,c,d, Junnan Xu a,b,d,✉

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Abstract

Background

Breast cancer (BC) remains a major global health concern, accounting for 11.7% of all cancer cases and ranking as the second leading cause of female cancer-related deaths worldwide. Increasing evidence highlights the interplay between gut microbiota (GM) dysbiosis and obesity-associated metabolic dysfunction in BC progression. This review aims to elucidate the role of GM in obese patients with BC.

KEY MESSAGES

Systematic integration of gut microbiota, obesity, and breast cancer interactions.

Gut dysbiosis resulting from obesity exacerbates breast cancer via immune pathways.

Probiotics inhibit breast cancer, mitigate high-fat diet-induced obesity, and dietary modulation of gut microbiota metabolites improves breast cancer prognosis.