Cancer -----Apoptosis

               Apoptosis

   

Apoptosis is programmed cell death are natural

Barriers that restrict malignant cells from 

Surviving and disseminating .

But cancer cells evolve various strategies

To evade programme cell death by generating 

Genetic mutations.

Metastasis is crucial for cancer progression

Let us know what is metastasis  

It is a process by which primary  tumour 

Spreads to different parts of the body it may be 

To near places or distant places.

Metastasis; cancer cell

1 Degeneration of extra cellular  matrix

2 Tumour angiogenesis means blood vessels 

     Formation

3  Defects in programme  cell death

4  Invasion

5 migrate to circulation

6 capillary bed adhere to vessel walls

Programme cell death

For this topic Year 2002 jointly

Nobel prize was awarded

Genetic Regulation of organ  development 

And programme cell death

To

Sydney Brenner 

H.Robert Horvitz 

John E Dumating

1 Apoptosis

2 Autophagy 

3 Necroptosis

1 Apoptosis blocks metastatic dissemination

 

   By killing misplaced cells

 The success of metastatic process

Relies on the ability of malignant cell

To escape apoptosis.

2 Autophagy self digesting

During early stages of cancer metastasis

Autophagy may act as a suppressor  of

Metastasis.

During the advanced  stages of metastasis

Autophagy tends to act as a promotor

Of .Metastasis.

  

3 Necroptosis 

It is also a type of programmed cell death

Necrosis is accidental unregulated cell death

Caused by physical trauma

Regulated necrosis is Necroptosis

Ref   Mol Cancer 2015 14:48

Zhenyi Su

       

         Sushant Yang (-------)and Kiang Yu