Chronological age is calander
Age which is added every year eg two persons born in same year
And completed 70 years will have same chronological age
Activity wise may be different one could go to the market independently
But other needs help of other while walking. This is because they have different biological age the active person is biological age is less than
His chronological age.
On the other hand less active dependent person biological age may be 80
Years more than his chronological age 70
So we now know Biological age.
So let us know predictors of biological age as reported in Ref 1
List of predictors
1 Epigenetic clocks
2 Telomere length
3 Transcriptomic
4Composite Biomarker
5 Proteonomic predictor
6 Metabolic based
Highlights
1 Telomere length most well studied
2 Epigenetic clock correlates with age predictor
And also predicts mortality
Some individuals requre assistance in daily routines already
In their 70s whereas others remain independent of assistance
And seemto escape major physiological deterioration until very
Extreme ages .
American Federation In Aging Research :
Criteria For Ageing Biomarkers
1 Must predict the rate of Aging . Must be a better predictor of life span than
Chronological age.
2 Monitor a basic process that underlines the aging processes not the effects of disease.
3 Tested repeatedly without harming a person.
4 works in human and mice
Telomere Length
Telomere which is shorten every time cell divide thus Telomere length is a popular
Marker of biological ageing .
Today greater than 6000 publications exist on the topic 'Telomere length'
Women on average have longer Telomere than men.
Hence women have a lower Biological age than means judged from Telomere Lengths.
Ref E Bio Medicine 2017 Jul 21.29-36Published Online 2017 April1
doi 10.1016/j .e biom.2017.03.046
Juulia Jylhava
Nancy L.Pedersen
And Sara Hagg
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