Air Pollution Threat
For HDL Function
HDL simply means good cholesterol
which absorbs
Cholesterol from the blood and
carries It back to the liver .
Liver flushes it From the body .
We daily read in News paper about Air
Pollution PM 2.5 ,PM 10 nitrogen oxides
Etc
Let us know What is air pollution?
Air Pollution a complex mixture of particles
Gasses and chemicals.
Inhale able air particulate matter (PM)
Is classified in to PM 10 (course ,Diameter
Less than 10micron M
PM 2.5 (fine diameter less than 2.5micron M
Gaseous pollutants nitrogen oxides
SO2 carbon monoxide Ozone
Incidence of cardiovascular
Events arise mainly from PM2.5
PM 2.5 is considered the most
Harmful fraction of air pollution.
Air pollution is now considered a modifiable
Risk factor for atherosclerotic cardiovascular disease.
Oxidative stress and inflammation triggered
By air pollutants can be responsible for the
development and progression of
Atherosclerosis :means built of fats cholesterol
And other substances inside and
on the arterial wall.
in exposed subjects by directly
damaging the arterial wall and/or by favouring
The development of other pro-atherogenic
(Atherogenic:Promote the formation of
Fatty deposits in arteries.)
Conditions as hypertension and dyslipidemias.
Dyslipedima: means imbalance of lipids
Cholesterol,LDL cholesterol HDL cholesterol
Triglycerides
Recent evidence suggests a
detrimental effect of air pollution on HDL
Function which can contribute to Atherosclerosis.
Overall the HDL system which exerts key
Protection to maintain vessel wall integrity
Is sensitive to the detrimental effects of
Several pathological conditions and air pollution
Seems to be the later name.
Ref Int J Mol Sci 2023 Jan :24(1):317
Alice Frank
Federica Cetti and Monica Gomaraschi
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