Superagers Memory

Superagers Memory 

Cognitive (Thinking Reasoning 

Remembering) abilities , particularly 

Memory , normally decline with age .

However some individuals ,often designated

As superagers (Age 80+)can reach late life 

With the memory function of individuals 

30 years younger .

 Study included 64 Superagers  mean age81.9

Years. Women 38 and men 26.

And

  55 Typical older adults mean age 82.4

35 women and 20 men.

               Superagers :

          Exhibited higher grey matter volume

(Meaning of Gray matter :essential type

Of tissue in your brain and spinal cord

Functions memory emotions and movement

Grey matter can be affected in stroke

Alzheimer's and Parkinson's disease.)

  Cross

Sectionally in Medial Temporal  lobe.

(Meaning  Medial Temporal Lobe:

Includess  1 Hipocampus 2 Amygdala

3 Para Hypocampal region

Medical Temporal Lobe  crucial

For Episodic and spatial memory)

Cholinergic fore brain and motor

Thalamus

Longitudinally  superagers also showed

Slower total grey matter atrophy 

Particularly within the medial Temporal

Lobe than did typically older adults.

Let us know the meaning of

1 Cholinergic :nerve cells in which 

   Acetylcholine acts as neurotransmitter

2 Fore Brain  : complex cognitive activities

    Composed of Mid Brain and hind brain.

3 Motor Thalamus : movement and 

    Sensory information from  body to your

     Brain.

4 Atrophy : decrease in size or wasting

Away of a body part or tissue.

          

       A machine learning  classification including 

89 demographic lifestyle ,and clinical

Predictors showed that faster movement

Speed and better mental health were 

The most differentiating factors for

Superagers .

              Similar concentrations of  dementia

(Impaired ability to remember think or

Make decision)

Blood biomarkers in superagers and typical

Older adults group suggest that group 

Differences reflect inherent superagers

resistance to typical age related memory

loss.

                    Episodic memory (is the memory 

Of everyday events ),the memory of personal

Life experiences,  is one of cognitive domains

That is most vulnerable to age-related 

Deterioration .Whereas neurodegenerative

Disease such as 

(Alzheimer's Parkinson's most common)

Alzheimer's disease are often accompanied

By a severe decline in episodic memory 

Some reduction in episodic memory 

Performance is also expected as a part of

Normal ageing .

           However some older adults often

termed superagers appear to resist this 

age-associated decline and instead show

an episodic memory that is as good as that

Of healthy adults 20 -30 years younger .

     Neuroimaging studies have shown that 

  Superagers have higher hippocampal

Volumes .

Thicker anterior cingulate cortices and

Slower cortical atrophy than that do typical 

older adults .

     One possible explanation for preserved

Brain structure in the superager  phenotype

Is that these individuals are born with 

Larger brains ,which results in age related 

Atrophy that is less evident than that of

Typical older adults.

However superagers  show a reduced 

Atrophy in the entire brain cortex and

Circumscribed memory related areas

Such as the anterior hippocampus and

The cholinergic basal fore brain.

Superagers show better mental health

Than do the typical older adults.

         Superagers are faster in both 

Gait speed and finger tapping than a control

Group.

Let us know meaning of

1 Neuroimaging MRI study focuses on Brain

    Health

2 Hippocampal volume MRI study

   Hippocampus : Region of the brain

     That is associated  primarily with memory

    Learning and encoding memory 

3  Anterior cingulate cortices  is extensive

   area of

   Limbic system implicated in pain processing

    Limbic system the part of the brain 

   Involved in our behavioural and emotio  nal 

   Responses.

4 Phenotype individuals observable traits

    Genotype a set of genes .

5 Cholinergic Basal acetylcholine originates

   In basal fore brain 

6 Gate speed walking without assistance

  

7 Finger tapping : Quantitative tool

Used to motor to measure motor 

Performance in upper extremities 

     

Ref The Lancet Healthy longevity 

        Vol 4 Issue E 374-E385 August 2023

         Garo - Pascual ,Marta

           Gaser Christian

            Zhang  Linda 

            Tohka.  Jussi

           Strange.   ,Bryan A