Hypoglycemia, a common consequence of diabetes treatment, is associated with severe morbidity and mortality
and has become a major barrier to intensifying antidiabetic therapy
Mild hypoglycemia can cause troubling symptoms such as anxiety, palpitations, and confusion.
Dementia generally refers to the loss of memory, language, problem-solving, and other
cognitive functions, which can interfere with daily life,
and there is growing evidence that diabetes
is associated with an increased risk of both vascular and non-vascular dementia.
Neuroglycopenia resulting from a hypoglycemic episode in diabetic patients can lead to the
degeneration of brain cells,
with a resultant cognitive decline, leading to dementia.
In light of new evidence, a deeper understating of the relationship between hypoglycemia and dementia
can help to inform and guide preventative strategies.
AHypoglycemia is a known adverse effect
of glucose-lowering therapies. Hypoglycemia is defined as plasma glucose levels below 70 mg/dL, as per the American Diabetes Association guidelines [1]
Multiple diabetic drugs can induce hypoglycemia, predominantly including, but not limited to, insulin in type 1 diabetes (T1D) and type 2 diabetes (T2D), and sulfonylureas (in T2D); there have also been associations with biguanides and thiazolidinediones [4]. With the onset of hypoglycemia,.
The prevalence of hypoglycemic episodes ranges from 10% in T2D to 50% in T1D; however, despite the overall prevalence, the relationship between hypoglycemia and dementia
typically refers to the elderly population as, over time, there is a reduced awareness of hypoglycemic symptoms, in addition to reduced counter-regulatory glucagon secretion [7,8]. Combined, these effects amplify the hypoglycemic risk of glucose-lowering therapies in elderly patients [9,10
There is increasing evidence that hypoglycemic episodes in patients with diabetes are a risk factor for dementia
Ref
. 2023 Jun 7;24(12):9846. doi: 10.3390/ijms24129846
No comments:
Post a Comment