Dementia In Diabetes Part2

  Hypoglycemic Events in Type 1 and Type 2 Diabetes Mellitus

A randomized controlled trial conducted on patients with T1D reported a threefold increase in severe hypoglycemia in

 intensively treated versus conventionally treated patients [14],

 with intensive therapy involving three or more daily injections 

of insulin as opposed to one and two insulin injections daily

 in the conventional therapy group. 

Moreover, approximately 2–4% of deaths in people with T1D are due to hypoglycemia [15]. 

A study was undertaken in which patients with

 T1D and T2D (n = 267) were randomly surveyed,

 recording the number of

 hypoglycemic events within a period of 4 weeks [16].

 The results showed that 155 diabetes patients 

reported 572 incidents of hypoglycemia. 

In T1D patients, these numbers equate to a rate 

of ~43 hypoglycemic events per patient per year, 

whereas insulin-treated T2D patients experience a rate 

of ~16.4 events per patient per year. 

Self-reports of hypoglycemia in T2D patients were 

lower than those of T1D; however, the authors 

concluded that, in insulin-treated T2D patients, hypoglycemia (significant enough to cause morbidity) occurs more often 

than is reported [16]. Furthermore, it is more difficult to obtain da

ta regarding T2D due to how much it varies in different regions [17]. Typically, patients with T2D diabetes are middle-aged/elderly, 

and therefore accurate figures for the

frequency of hypoglycemia may be markedly underestimated [18].

Int J Mol Sci

. 2023 Jun 7;24(12):9846. doi: 10.3390/ijms24129846

Dementia in Diabetes: The Role of Hypoglycemia

Khaled Hameed Husain 1, Saud Faisal Sarhan 1, Haya Khaled Ali Abdulla AlKhalifa 1, Asal Buhasan 1, Abu Saleh Md Moin 2,†,‡, Alexandra E Butler 2,*,†,‡

Editor: Masashi Tanaka