Glycemic Control and Dementia

 

             Glycemic Control and Dementia

HbA1c is widely used to determine glycemic control over the previous 3-month time span. 

Hence, the majority of studies use HbA1c when assessing glycemic control and dementia risk, 

with tight glycemic control 

referring to HbA1c levels below 7.0% (53 mmol/mol). 

Many studies identified an association 

between increasing HbA1c levels and

 increased risk of dementia.

 A large UK cohort study including 372,287 patients with

 both T1D and T2D reported an HR of 1.08 (1.07, 1.09) of developing dementia for every 1% increase in HbA1c. 

If tight glycemic control can be attained

 (HbA1c level below 6%), the HR for dementia 

development drops to 0.86 (0.83–0.89) [63]. 

A meta-analysis by Tang et al. also showed

 that tight glycemic control can slow 

cognition decline, especially in terms of memory [64].

Ref

Int J Mol Sci 2023 Jun 7;24(12):9846. doi: 10.3390/ijms24129846

Dementia in Diabetes: The Role of Hypoglycemia

Khaled Hameed Husain 1, Saud Faisal Sarhan 1, Haya Khaled Ali Abdulla AlKhalifa 1, Asal Buhasan 1, Abu Saleh Md Moin 2,†,‡, Alexandra E Butler 2,*,†,‡

Editor: Masashi Tanaka