Conclusions
Aspartame is an additive used to sweeten a variety of beverages and foods,
such as desserts, cakes, chewing gum, yogurt, low-calorie
And weight-control products, and even drugs for oral administration
.
Its presence in foods can be indicated either
by name or by its code E951.
Following ingestion, aspartame breaks down in the
gut into the following three constituents:
aspartic acid, phenylalanine, and methanol.
These components are also naturally present in other foods, including fruits and vegetables, and for foods containing aspartame, they are processed by the body in the same way as those derived from other dietary sources
. Following a detailed and methodical analysis,
European Food Safety Authority [60] experts
concluded that aspartame and
its breakdown products are safe for
human consumption at current levels of exposure.
The current ADI is considered to be safe for the general population, although some clinical [42] or in vivo animal studies [38]
suggested neurobehavioral effects upon daily aspartame intake below or at ADI
Questions have primarily been raised about the early
experimental animal studies used to evaluate the
safety of aspartame.
Some subsequent studies concluded that there is sufficient scientific evidence to confirm that aspartame is generally safe for human consumption up to the maximally recommended daily intake doses.
However, its use may pose health risks for certain individuals,
Like patients with seizures or other neurological conditions;
it is strictly forbidden for patients with phenylketonuria
Andshould be restricted if not completely eliminated during pregnancy.
It is also highly advisable that each aspartame-containing product lists explicitly the exact amount of aspartame on its label.
The association between high-dose aspartame usage
and increased risk of developing cancers, such as brain tumors or non-Hodgkin lymphomas, is still highly controversial and under investigation and seems to be confirmed by some recent cohort studies.
Ref. Nutrients. 2023 Aug 18;15(16):3627. doi: 10.3390/nu15163627
Aspartame Safety as a Food Sweetener and Related Health Hazards
Shurooq Asaad Abdulameer Shaher 1,2, Dan Florin Mihailescu 1, Bogdan Amuzescu 1,*
Editor: Philip J Atherton
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