Sucralose Sweet SuccessTo Metobolic Controversies

 Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity.

 Although sucralose has been considered safe for human consumption,

 The World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implications of this artificial sweetener. 

This review aims to comprehensively explore the effects of sucralose intake on human health by understanding sucralose absorption, metabolism, and excretion.

 We also outline the role of the sweet taste 1 receptor 3 (T1R3) in mediating sucralose-dependent signaling pathways that regulate satiety, incretin release, and insulin response. 

Finally, we discuss the impact of sucralose on microbiome dysbiosis, inflammatory response origin, liver damage, and toxicity. 

Gaining a deeper understanding of the manifold effects of sucralose on human physiology will help promote further studies to ensure its consumption is deemed safe for a broader population, including children, adolescents, and pregnant women.

Introduction

Sucralose, a prevalent food additive, is utilized to impart sweetness to foods without contributing a substantial

 caloric load .

It dominates the global sweetener market,

 comprising 30% of the United States sweetener market [2]. 

Present in over 4500 food and beverage items, sucralose plays a pivotal role in the food industry and is projected to strengthen its market presence [2,3].

Discovered in 1976 by Shashikant Phadnis, sucralose, chemically identified as 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside, is an artificial sweetener derived from sucrose [4,5]. 

Produced through selective halogenation,involving  the 

addition of three chlorine atoms to the sucrose molecuule.

Produced through selective halogenation, involving the addition of three chlorine atoms to the sucrose molecule, 

This process diminishes intestinal absorption.

Originally intended for 

individuals with obesity and diabetes due to its ability to avert glycemic spikes and reduce caloric intake while maintaining sweetness [6], 

sucralose has become a ubiquitous sweetener across diverse demographics.

 Boasting unique characteristics such as prolonged solid-state stability and resilience in solutions with varying pH levels [7], 

It remains 600 times sweeter than regular sugar

, with a bacteriostatic effect that prevents dental caries

 

For years, sucralose has been regarded as a harmless substance.

 In 1998, the Joint Committee of Experts on 

Food Additives of the WHO/FAO within the United Nations classified this sweetener as a safe product [10]. 

The FDA has also stated that sucralose is safe for consumption by children and individuals with diabetes [11]. 

The WHO has reported an acceptable daily intake for this sweetener at 15 mg/kg of body weight [12]. 

Sucralose initially appeared to offer a fresh solution to the rising rates of obesity and metabolic diseases [13].

 However, despite the apparent harmlessness of sucralose, the World Health Organization (WHO) has recently issued an alert indicating that sucralose consumption may be linked to systemic inflammation and metabolic diseases [14].

Next information from following ref willbe on taste

Of Sucralose

Ref

Life (Basel). 2024 Feb 29;14(3):323. doi: 10.3390/life14030323

Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener

José Alfredo Aguayo-Guerrero 1, Lucía Angélica Méndez-García 1, Helena Solleiro-Villavicencio 2, Rebeca Viurcos-Sanabria 3, Galileo Escobedo