Sucralose( Artificial Sweetener )Metabolism

         Sucralose constitutes a modified

   sucrose molecule with three chlorine atoms replacing three hydroxyl groups [13].

 This minor structural alteration induces substantial functional changes

Metabolism means both constuctive and destructive activities.

                 Sucralose                       Sucrose

1.  Origin.    Artificial.                      Natural

2 Molecule.   Hydrophobic.             Hydrophilic

 3Binding to the                                poorly absorbed by taste buds

 T1R3 receptor

 in taste bud Absorbed more

 intensively by the taste buds.

4 caloric intake.       Low.                           High

5 Effect on glycemia                            Increases blood glucose

minimal impact 

on blood glucose levels, 

but recent evidence has 

prompted us to

 reevaluate this aspect. 

 6Metabolism                            

84% not absorbed.                                          Metabolizes 

                                                                       in glucose and fructose

    7 sweetness  600.                                 Sucrose 1time sweet

      Times more than 

   Sucrose

        

      It is noteworthy that sucralose can persist in the bloodstream for over 18 h post-ingestion [2]. 

Furthermore, observations indicate that this sweetener can traverse the placenta, reaching the fetus in pregnant women, and is also present in breast milk [2,17]. 

Concerns regarding the duration of sucralose in the body have been raised by researchers. A study by

 Bornemann et al., involving rats consuming sucralose for 40 days, reported the detection of acetylated metabolites

 in urine up to 11 days after the last dose [18].

The study also revealed sucralose presence 

in rat adipose tissue up to two weeks post the final dose [18], presenting results contradictory 

to prior data.

 Hence, further research is imperative to comprehend the persistence of sucralose and

 the effects of its metabolites in the body.Conntrary to expectations, the bioavailability of

 sucralose in the human body varies with age. 

Sylvetsky et al. determined that children consuming a 300 mL diet drink exhibit plasma concentrations of sucralose twice as high as adults [19]. Sylvetsky suggests that this may be attributed to children’s lower glomerular filtration rate.  

Ref

Life (Basel). 2024 Feb 29;14(3):323. doi: 10.3390/life14030323

Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener

José Alfredo Aguayo-Guerrero 1, Lucía Angélica Méndez-García 1, Helena Solleiro-Villavicencio 2, Rebeca Viurcos-Sanabria 3, Galileo Escobedo