Parkinson's Disease

Parkinson's Disease:

First medically described by James Parkinson in 1817.

PD  is the second most common age related neurodegenerative disorder after Alzheimer's disease.

Incidence: 7-10 million people have

PD .world wide.

 Age: Usual Onset age over 60 years.

How Parkinson's Develops:

Dopamine is essential for body movements 

Dopamine is secreted by neurons of 

Mid brain's region called substantia nigra

These neurons degenerate resulting in reduction in dopamine secretion this neurodegenerative disease is Parkinson's disease. Degenerated nerves show Levy bodies.

Parkinson's disease Causes : Idiopathic definite cause not known 

Yet.

Risk Factors:

1)Old age

2) Exposure to pesticides, herbicides and 

     Cleaning Chemicals

  3) magnese breathing

   4) Family History

     5) Gene mutation

    Early signs : 1)Reduced sense of 

      Smell  called hyposmia  may affect more than 95%of PD Lewy bodies have been captured in the nasal epithelium .

     2)Anxiety depression 

      

       3) Sleep dysregulation

         4) constipation

       Late signs of PD

        1) Shakyness of hand or finger

         2) Stiffnesss of  arm or leg

         3) Slow down movement  

          4) Problems with balance

           5)Constipation

    

          Treatment : Dopamine is required but due to blood brain barrier dopamine cannot get entry

The drug Levodopa gets entry and converts

Into dopamine in brain.

But mostly for better results Levodopa is given along with carbodopa.

Physical exercises requried as.advice.by physiotherapist.

 Take medical advice of your Doctor

Before taking any medicines.