Gut Microbiota Role Diabetes
MS Obesity
The gut microbiota comprising trillions of microorganisms
In the gastrointestinal tract is a key player in the development of
Obesity
And metabolic disorders such as Type 2 DM
metabolic syndrome (MS) and cardiovascular disease.
The studies show that GM dysbiosis is linked to increased energy
Extraction ,altered metabolic pathways ,and inflammation
,contributing to obesity MS and Type 2 diabetes.
What is GM
GM refers to the community of microorganisms
residing in the
GIT (gastrointestinal tract) consisting of commensal,symbiotic
and pathogenic microorganisms
While microbiome encompasses all the genetic material
Of that microbiota.
The healthy human GM(gut microbiota)
Comprises over 1000 bacterial species
GM and Obesity and Metabolic syndrome :
Recent literature suggests that GM dysbiosis
could lead to many
Diseases including obesity MS and T2D.
This occurs by decreasing microbial diversity
and number,
Modulating paracrine and endocrine functions ,changing
The energy metabolism influencing the satiety centres
In the brain and pathways of inflammation, and altering
The key functions performed by the microbes.
In T2D subjects there is reduction in bacteria protecting
The intestinal barrier ,such as
A.muciniphilia and Faecali
prausnitzii, and an increase in bacteria that damage
the international barrier such as Escherichia coli
Gut microbial metabolites Such as TMAO
May contribute to IR and T2D
IR insulin resistance
T2D type 2diabetes
Ref J Clin Endocrinology Mettab 2024 Jul23 :109(11):2709-2719
Sabitha Sasidharan Pillai
Charles A Gagnon
Christy Foster
Ambika O Ashraf
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