Coffee Intake and Longivity

    The Impact Of Coffee Intake

The conception of There consumption has undergone 

a profound modification ,evolving from noxious

Habit into a safe life style actually a preserving human health

The last 20years also provided strikingly consistent epidemiological evidence 

Showing that the regular consumption of moderate doses of coffee attenuates 

all cause mortality an effect observed in over 50 studies indifferent geographical 

regions and different ethnicities.

       Impact of Coffee intake on Longivity

Coffee is the most consumed beverage after water with

2.5 billion cups consumed every day.

   Coffee is a mixture of over 2000 potentially bioactive 

Substances with particularly high levels of chlorogenic acids

And caffeine and with other substances .Such as melanoidns,

Diterpenes and Trigoneelline.

        Several beneficial effects have been  associated to

   melanoidins Such as antioxidant ,antimicrobials , anti-inflammatory,and probiotic Activity .

          Coffee Intake and life span

    In fact epidemiological studies concur in deducing

   That regular consumption of moderate doses of coffee is

Associated is  with an increased life span.    

Conclusion    emerging from both meta-analyses

And narative reviews .

  This association was noted in over 50 different cohort analzed

In different geographical locations notably stronger associations

 are  found in Europe and Asia than in US.

Who benefits from the impact of coffee on life span?

The risk ratio linking coffee consumption and all cause mortality 

Is computed between 078and 0.94

(Means no association and values below 1 means on increasingly

Stronger inverse association) These values of risk ratio correspond

To an estimated 15,%lower likliness of dyeing during analysed

Periods to gain of 1.84years of life expectancy to coffee intake

Using Chiangs life table or 4.70-9.1%of estimated years of life 

  It is important to keep in mind hat odddds ratios are average

Values applicable to whole population studied ,where some more

Individuals benefit by drinking coffee where as others may suffer 

Deterimental effects upon coffee consumption , in accordance with

Inter individuals differences in caffeine .

    Increased life span attributed to coffee consumption is observed 

In men and women. 

   Dose dependent effects of coffee 

On life span 

Accordingly several epidemiological studies and meta studies and meta analysis

Concluded that benefits of coffee consumption on life span follow a J shaped curve

With discrete benefits afforded.

The consumption of 1cup of coffee a day , maximum  benefits afforded by 3cups

a day followed by waning of the benefits with increasing doses of coffee consumed

Daily 

Negative impact of high doses of coffee 

Intake on behavior of adults ,typified  by symptoms such as heightened anxiety

Agitation restlessness headache , insomnia and gastric distress .

Coffee intake attenuates age associated diseases .

Coffee intake preserseves the main biological mechanisms of aging

Ref Aging Research Reviews vol 102 Dec 2024 , 102581

Catia  R Lopes 

Rodrigo A  Cunha