Blueberry Supplementation in midlife for dementia Risk

 

Blueberry Supplementation in Midlife for Dementia Risk Reduction

Late life Dementia develops over a peoid of many

  years  in midlife.

  Preliminary stuudies  Randomized( n=33) double blind

Placebo control trial  evaluating the effect of the Blue berry 

Supplemmentation on cognitive performance in non diabetic

,middle age over weight men and women with subjective  cognitive decline.

Participants aged 50-60years who had gained weight 

In the mid life and were aware of having developed

Cognitive inefficiency BMI =25 or greater.

 Blue berry supplemmentation 

The blueberry group  daily Blueberry powder supplementation 

Equivalent of 0.5c whole fruit for 12 weeks.

Can improve cognitive performance and metabolism and brain

Function and therefore may have role in early intervention to

Prevent neurodegeneration.

     

 Blue Berry group on measures of Lexical access  p= 0.003

And memory interference ,p=0.04 ,and Blue berry treated 

Participants  reported reduced memory encoding difficulty in

Daily life activities p=0.03

 The Blue berry treated group also exibited correction of peripheral 

Hyperinsulenimia  p=0.04 and modest trend for increased mitochondrial

Uncoupling p= 0.11.

The cognitive ability improved executive ability in middle aged.

    Nearly six million older  adults live with dementia 

In the USA .Alzheimer's disease accounts for up to 80% dementia cases.

 Unfortunately nearly 50% of middle aged adults

In the US have insulin resistance a condition that

Insulin  involves  insulin receptors insensitivity and

Compensatory increase in insulin secretion.Thus insulin resistance is 

Hyperinsulenimia state.

Peripherals hyperinsulenimia is associated with reduced insulin transport

Into the brain and central hypoinsulenemia promotes 

Neurodegeneration through reduction in neurotrophic factors

Greater retention of  amyloid beta a pathological  feature of

Alzheimer's disease.

 

Accelerated accumulation of beta amyloid in the brain tends to

Begin  after the age of 50years.:

Discussion:

Daily Blueberry Powder supplementation equivalent of 0.5c

Whole fruit for 12 weeks improved performance on Lexical 

Access task and reduced interference of extraneous information 

In memory.

These cognitive performance  enhancements can be

 understood as reflecting improved exicutive control among

The Blue berry treated participants.

Blue berry supplemmentation can produced measureable cognitive 

Benefits in the context of aging and insulin resistance.

 

Ref Nutrients 2022 April13:14(8):1609

doi:10.3390/nu1408

Robert krikorian

Mathew R Skelton

Suzanne  S sammer

Marcelle D Shidler

Patric G Sullivan