Diabetes & Glycemic variability

Diabetes & Glycemic

Variability

Glycemic means blood glucose level 

Normal glucose tolerance

Glycemia maintained between 68.4mg

And 138.6mg,/dl

When it is low called as hypoglycemia

When high called as hyperglycemia

Glycemic variability means blood glucose

Variation that occur throughout the day.

Post prandial spikes in blood glucose

As well as hypoglycemic events are blamed 

For increase cardiovascular events in diabetes.

Gv

Includes both the above events hypoglycemia and hyperglycemia.

Hence need for minimising GV which

can prevent cardiovascular events.

GV which refers to swings in blood glucose

Levels.Blood glucose oscillations that occur

Through out the day.

Intra day glycemic excursions , includes

Episodes of hypoglycemia and hyperglycemia.

Microvascular (small blood vessels) and

Microvascular (large vessels)

Complications in diabetes is attributed to

Hyperglycemia and dysglycemia  (peaks and

Nadirs )

HbA1c :Time average glucose

Values measured .

HbA1c has become reference parameter 

For therapies aimed at reducing the risk 

Of complications from diabetes. 

Chronic hyperglycemia is almost universally

Assessed by HbA1c.

HbA1c is poor predictor

Of hypoglycemic risk,whereas GV

Is the strong predictor of hypoglycemic 

Episodes.

It is advisable  to make every effort

To maintain stable glycemic values.

Ref  Diabetes and Metabolism  Journal

         2015 Aug ; 39(4):273-282 

          Sunghwan Suh 

And Jae Hyeon Kim

Cardiovascular events.