Superagers Memory
Cognitive (Thinking Reasoning
Remembering) abilities , particularly
Memory , normally decline with age .
However some individuals ,often designated
As superagers (Age 80+)can reach late life
With the memory function of individuals
30 years younger .
Study included 64 Superagers mean age81.9
Years. Women 38 and men 26.
And
55 Typical older adults mean age 82.4
35 women and 20 men.
Superagers :
Exhibited higher grey matter volume
(Meaning of Gray matter :essential type
Of tissue in your brain and spinal cord
Functions memory emotions and movement
Grey matter can be affected in stroke
Alzheimer's and Parkinson's disease.)
Cross
Sectionally in Medial Temporal lobe.
(Meaning Medial Temporal Lobe:
Includess 1 Hipocampus 2 Amygdala
3 Para Hypocampal region
Medical Temporal Lobe crucial
For Episodic and spatial memory)
Cholinergic fore brain and motor
Thalamus
Longitudinally superagers also showed
Slower total grey matter atrophy
Particularly within the medial Temporal
Lobe than did typically older adults.
Let us know the meaning of
1 Cholinergic :nerve cells in which
Acetylcholine acts as neurotransmitter
2 Fore Brain : complex cognitive activities
Composed of Mid Brain and hind brain.
3 Motor Thalamus : movement and
Sensory information from body to your
Brain.
4 Atrophy : decrease in size or wasting
Away of a body part or tissue.
A machine learning classification including
89 demographic lifestyle ,and clinical
Predictors showed that faster movement
Speed and better mental health were
The most differentiating factors for
Superagers .
Similar concentrations of dementia
(Impaired ability to remember think or
Make decision)
Blood biomarkers in superagers and typical
Older adults group suggest that group
Differences reflect inherent superagers
resistance to typical age related memory
loss.
Episodic memory (is the memory
Of everyday events ),the memory of personal
Life experiences, is one of cognitive domains
That is most vulnerable to age-related
Deterioration .Whereas neurodegenerative
Disease such as
(Alzheimer's Parkinson's most common)
Alzheimer's disease are often accompanied
By a severe decline in episodic memory
Some reduction in episodic memory
Performance is also expected as a part of
Normal ageing .
However some older adults often
termed superagers appear to resist this
age-associated decline and instead show
an episodic memory that is as good as that
Of healthy adults 20 -30 years younger .
Neuroimaging studies have shown that
Superagers have higher hippocampal
Volumes .
Thicker anterior cingulate cortices and
Slower cortical atrophy than that do typical
older adults .
One possible explanation for preserved
Brain structure in the superager phenotype
Is that these individuals are born with
Larger brains ,which results in age related
Atrophy that is less evident than that of
Typical older adults.
However superagers show a reduced
Atrophy in the entire brain cortex and
Circumscribed memory related areas
Such as the anterior hippocampus and
The cholinergic basal fore brain.
Superagers show better mental health
Than do the typical older adults.
Superagers are faster in both
Gait speed and finger tapping than a control
Group.
Let us know meaning of
1 Neuroimaging MRI study focuses on Brain
Health
2 Hippocampal volume MRI study
Hippocampus : Region of the brain
That is associated primarily with memory
Learning and encoding memory
3 Anterior cingulate cortices is extensive
area of
Limbic system implicated in pain processing
Limbic system the part of the brain
Involved in our behavioural and emotio nal
Responses.
4 Phenotype individuals observable traits
Genotype a set of genes .
5 Cholinergic Basal acetylcholine originates
In basal fore brain
6 Gate speed walking without assistance
7 Finger tapping : Quantitative tool
Used to motor to measure motor
Performance in upper extremities
Ref The Lancet Healthy longevity
Vol 4 Issue E 374-E385 August 2023
Garo - Pascual ,Marta
Gaser Christian
Zhang Linda
Tohka. Jussi
Strange. ,Bryan A