Lung cancer Types

 2.1. Histological Subtypes of Lung Cancer

 

Ref

Int J Mol Sci. 2025 Apr 17;26(8):3818. doi: 10.3390/ijms26083818

The Current Roadmap of Lung Cancer Biology, Genomics and Racial Disparity

Enas S Alsatari 1,2, Kelly R Smith 1,2, Sapthala P Loku Galappaththi 1,2, Elba A Turbat-Herrera 1,2, Santanu Dasgupta 1,2,3,*

Editor: Robert Arthur Kratzke

Lung cancer is divided into two major groups: small-cell lung cancer

 (SCLC) and non-small-cell lung cancer (NSCLC).

 SCLC is aggressive and has a high risk for distant metastasis at initial diagnosis [11] and accounts for 12% of all lung cancer cases [12].

 NSCLC is, conversely, the most common group, representing 80% to 85% of the lung cancer cases [13].

 Among the NSCLC, adenocarcinoma (LUAD) is the most common histologic subtype, accounting for 45% of all cases, 

followed by squamous cell carcinoma (LUSC) at 21% of cases, 

while 23% attributed to unclassified histologic subtypes [12]. Notably, LUAD is more common in never-smokes with a predominant EGFR gene mutation, whereas LUSC is more common among smokers with a predominant TP53 gene mutation [14,15].