Obesity and Dementia link

 

          Abstract

Obesity is a major global health concern

With prevalence rates rapidly rising due to increased availability 

Of highly processed foods,rich in fats and or sugars and

Technological advances promoting more sedentary behaviour 

There is increasing evidence to suggest that

Obesity predisposes individuals to developing cognitive

Impairment and dementia.

However  the relationship  between the brain and the 

Peripheral  metabolic state is complex and many of the

Underlying mechanisms of cognitive impairment in

Obesity are yet to be fully elucidated.To better understand 

the links between obesity and dementia further work is required to

determine .To better understand the links between obesity

To better understand the links between obesity and Dementia further

Work is required to determine pathological changes occurring in

Brain during obesity.In this mini review,

We discus the role of two pathological features of obesity

(the gut brain axix  and systemic inflammation) and their 

potential contribution 

to dementia.

     we discuss the role of two pathological features of obesity (the gut-brain axis and systemic inflammation) and their potential contribution to dementia.

Ref

Neuromolecular Med

. 2023 Apr 22;25(4):451–456. doi: 10.1007/s12017-023-08746-1

Pathophysiological Links Between Obesity and Dementia

David E Wong Zhang ^1,#, Vivian Tran ^1,#, Antony Vinh ¹, Quynh Nhu Dinh ¹, Grant R Drummond ¹, Christopher G Sobey ¹, Maria Jelinic ^1,#, T Michael De Silva ^1,✉,#